A pleiotropic chemoreceptor facilitates the functional coupling of pheromone production and perception
Vernier, C.; Zelle, k.; Leitner, N.; Liang, X.; Halloran, S.; Millar, J.; Ben-Shahar, Y.
Show abstract
Optimal mating decisions depend on the robust coupling of signal production and perception because independent changes in either could carry a fitness cost. However, since the perception and production of mating signals are often mediated by different tissues and cell types, the mechanisms that drive and maintain their coupling remain unknown for most animal species. Here, we show that in Drosophila, sensory perception and production of an inhibitory mating pheromone are co-regulated by Gr8a, a member of the Gustatory receptor gene family. Specifically, we found that the pleiotropic action of Gr8a independently regulates the perception of pheromones by the chemosensory systems of males and females, as well as their production in the fat body and oenocytes of males. These findings provide a relatively simple molecular explanation for how pleiotropic receptors maintain robust mating signaling systems at the population and species levels.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- fruitless tunes functional flexibility of courtship circuitry during development 97%
- The yellow gene influences Drosophila male mating success through sex comb melanization 96%
- Neuronal octopamine signaling regulates mating-induced germline stem cell proliferation in female Drosophila melanogaster 96%
Similar papers in this journal
- CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression 95%
- MYCBP interacts with Sakura and Otu and is essential for germline stem cell renewal and differentiation and oogenesis 95%
- Ets Transcription Factor Pointed Controls Germline Survival In Drosophila 95%
Similar papers in this journal
- Octopaminergic/tyraminergic Tdc2 neurons regulate biased sperm usage in female Drosophila melanogaster 96%
- Imaginal disc growth factors are Drosophila Chitinase-like Proteins with roles in morphogenesis and CO2 response 95%
- Maternal Piwi Regulates Primordial Germ Cell Development to Ensure the Fertility of Female Progeny in Drosophila 95%
Similar papers in this journal
Similar papers in this journal
- Coordination Among Multiple Receptor Tyrosine Kinase Signals Controls Drosophila Developmental Timing and Body Size 96%
- Contributions of the conserved insect carbon dioxide receptor subunits to odor detection 95%
- Affinity Requirements For Control Of Synaptic Targeting And Neuronal Cell Survival By Heterophilic IgSF Cell Adhesion Molecules 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.