Evaluation of a predictive method for the H&E-based molecular profiling of breast cancer with deep learning
Raharja-Liu, P.; Arslan, S.; Li, X.; Schmidt, J.; Hense, J.; Geraldes, A.; Bass, C.; Brown, K.; Marcia, A.; Dewhirst, T.; Pandya, P.; Singhal, S.; Mehrotra, D.
Show abstract
We present a public validation of PANProfiler (ER, PR, HER2), an in-vitro medical device (IVD) that predicts the qualitative status of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) by analysing the hematoxylin and eosin (H&E)-stained tissue scan. In public validation on 648 (ER), 648 (PR) and 560 (HER2) unseen cases with known biomarker status, the device achieves an accuracy of 87% (ER), 83% (PR) and 87% (HER2). The validation offers early evidence of the ability to predict clinically relevant breast biomarkers from an H&E slide in a relevant clinical setting.
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