BDNF-induced BDNF release mediates presynaptic LTP and is regulated by cannabinoids
Berthoux, C.; Nasrallah, K.; Castillo, P. E.
Show abstract
The brain-derived neurotrophic factor (BDNF) and its effector Tropomyosin receptor kinase B (TrkB) mediate diverse forms of activity-dependent synaptic plasticity implicated in learning, neural circuit refinement, and brain diseases, including epilepsy and mood disorders. Here, we report that activity-dependent release of presynaptic BDNF elicits the release of postsynaptic BDNF in a TrkB- and calcium-dependent manner. This BDNF-induced BDNF release was required for the induction of presynaptic long-term potentiation (LTP) of excitatory transmission in the mouse dentate gyrus. Tonic and phasic activity of presynaptic type-1 cannabinoid receptors suppressed BDNF release and dampened LTP, while exposure to enriched environment elicited BDNF-mediated LTP. In addition to mediating presynaptic plasticity, BDNF-induced BDNF release could be an important mechanism in synaptic stabilization during the maturation and refinement of neuronal connections. One-Sentence SummaryThe brain-derived neurotrophic factor induces its own release to mediate long-lasting increase in neurotransmitter release.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Restoring Glutamate receptosome dynamics at synapses rescues Autism-like deficits in Shank3-deficient mice. 95%
- Elevated expression of complement C4 in the mouse prefrontal cortex causes schizophrenia-associated phenotypes 94%
- Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability 94%
Similar papers in this journal
- Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice. 95%
- Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells 95%
- Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum 94%
Similar papers in this journal
- Collagen VI regulates motor circuit plasticity and motor performance by cannabinoid modulation 95%
- Alterations of adult prefrontal circuits induced by early postnatal fluoxetine treatment mediated by 5-HT7 receptors. 94%
- A pathogenic missense mutation in kainate receptors elevates dendritic excitability and synaptic integration through dysregulation of SK channels 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.