Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers
Waheed, Q.; Zhou, H.; Ruoff, P.
Show abstract
Homeostasis plays a central role in our understanding how cells and organisms are able to oppose environmental disturbances and thereby maintain an internal stability. During the last two decades there has been an increased interest in using control engineering methods, especially integral control, in the analysis and design of homeostatic networks. Several reaction kinetic mechanisms have been discovered which lead to integral control. In two of them integral control is achieved, either by the removal of a single control species E by zero-order kinetics ("single-E controllers"), or by the removal of two control species by second-order kinetics ("antithetic or dual-E control"). In this paper we show results when the control species E1 and E2 in antithetic control are removed enzymatically by ping-pong or ternary-complex mechanisms. Our findings show that enzyme-catalyzed dual-E controllers can work in two control modes. In one mode, one of the two control species is active, but requires zero-order kinetics in its removal. In the other mode, both controller species are active and both are removed enzymatically. Conditions for the two control modes are put forward and biochemical examples with the structure of enzyme-catalyzed dual-E controllers are discussed.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- An amplified derepression controller with multisite inhibition and positive feedback 99%
- Coherent feedback leads to robust background compensation in oscillatory and non-oscillatory homeostats 98%
- Background compensation revisited: Conserved phase response curves in frequency controlled homeostats with coherent feedback 98%
Similar papers in this journal
- Dopamine depletion leads to pathological synchronization of distinct basal ganglia loops in the beta band 95%
- Ion dynamics at the energy-deprived tripartite synapse 95%
- Role of neutrophil extracellular traps in regulation of lung cancer invasion and metastasis: Structural Insights from a Computational Model 95%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.