midline represses Dpp signaling and target gene expression in Drosophila ventral leg development.
Phillips, L. A.; Atienza, M. L.; Ryu, J.-R.; Kelemen, L. K.; Svendsen, P. C.; Brook, W.
Show abstract
Ventral leg patterning in Drosophila is controlled by the expression of the redundant T-box Transcription factors midline (mid) and H15. Here we show that mid represses the Dpp-activated gene Daughters against decapentaplegic (Dad) through a consensus TBE site in the minimal enhancer, Dad13. Mutating the Dad13 DNA sequence results in an increased and broadening of Dad expression. We further demonstrate that the engrailed-homology-1 domain of Mid is critical for regulating the levels of phospho-Mad, a transducer of Dpp-signaling. However, we find that mid does not affect all Dpp-target genes as we demonstrate that brinker (brk) expression is unresponsive to mid. This study further illuminates the interplay between mechanisms involved in determination of cellular fate and the varied roles of mid. Summary statementVentral patterning is controlled in part by the T-box Transcription factor midline blocking Dpp signaling and Dpp-activated genes, though midline does not affect the Dpp-repressed gene brk.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The histone demethylase KDM5 controls developmental timing in Drosophila by promoting prothoracic gland endocycles. 96%
- Hedgehog produced by the Drosophila wing imaginal disc induces distinct expression responses in three target tissues 96%
- Ultrabithorax modifies a regulatory network of genes essential for butterfly eyespot development in a wing sector-specific manner 96%
Similar papers in this journal
- The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth 97%
- Extramacrochaetae regulates Notch signaling in the Drosophila eye through non-apoptotic caspase activity 96%
- Drosophila Hedgehog can act as a morphogen in the absence of regulated Ci processing 96%
Similar papers in this journal
- Ambivalent partnership of the Drosophila posterior class Hox protein Abdominal-B with the Extradenticle and Homothorax cofactors 97%
- Specification of the endocrine primordia controlling insect moulting and metamorphosis by the JAK/STAT signalling pathway 96%
- Ets Transcription Factor Pointed Controls Germline Survival In Drosophila 96%
Similar papers in this journal
- Conserved and divergent aspects of Robo receptor signaling and regulation between Drosophila Robo1 and C. elegans SAX-3 97%
- Selective disruption of synaptic BMP signaling by a Smad mutation adjacent to the highly conserved H2 helix 96%
- Imaginal disc growth factors are Drosophila Chitinase-like Proteins with roles in morphogenesis and CO2 response 95%
Similar papers in this journal
- Usp14 is required for spermatogenesis and ubiquitin stress responses in Drosophila melanogaster 95%
- Reduction of nucleolar NOC1 accumulates pre-rRNAs and induces Xrp1 affecting growth and resulting in cell competition in Drosophila 95%
- A region of Drosophila SLBP distinct from the histone pre-mRNA binding and processing domains is essential for deposition of histone mRNA in the oocyte 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.