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Structure of anchorless RML prion reveals motif variation between strains

Hoyt, F.; Standke, H. G.; Artikis, E.; Schwartz, C. L.; Hansen, B.; Li, K.; Hughson, A. G.; Manca, M.; Thomas, O. R.; Raymond, G. J.; Baron, G. S.; Caughey, B.; Kraus, A.

2021-12-22 biochemistry
10.1101/2021.12.22.473909 bioRxiv
Show abstract

Little is known about the structural basis of prion strains. Here we provide a high (3.0 [A]) resolution cryo-electron microscopy-based structure of brain-derived fibrils of the mouse anchorless RML scrapie strain which, like the recently determined hamster 263K strain, has a parallel in-register {beta}-sheet-based core. However, detailed comparisons reveal that variations in shared structural motifs provide a basis for prion strain determination. One-sentence summaryCryo-electron microscopy reveals a near-atomic structure of an infectious, brain-derived murine prion fibril and strain differences.

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