The transcription factor Zic4 acts as a transdifferentiation switch
Vogg, M. C.; Ferenc, J.; Buzgariu, W. C.; Perruchoud, C.; Papasaikas, P.; Sanchez, P. G. L.; Nuninger, C.; Delucinge-Vivier, C.; Rampon, C.; Beccari, L.; Vriz, S.; Vincent, S.; Galliot, B.; Tsiairis, C.
Show abstract
The molecular mechanisms that maintain cell identities and prevent transdifferentiation remain mysterious. Interestingly, both dedifferentiation and transdifferentiation are transiently reshuffled during regeneration. Therefore, organisms that regenerate readily offer a fruitful paradigm to investigate the regulation of cell fate stability. Here, we used Hydra as a model system and show that Zic4 silencing is sufficient to induce transdifferentiation of tentacle into foot cells. We identified a Wnt-controlled Gene Regulatory Network that controls a transcriptional switch of cell identity. Furthermore, we show that this switch also controls the re-entry into the cell cycle. Our data indicate that maintenance of cell fate by a Wnt-controlled GRN is a key mechanism during both homeostasis and regeneration. One-Sentence SummaryA Wnt-controlled GRN controls fate maintenance in Hydra.
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