Directed motor actions and choice signalling drive cortical acetylcholine dynamics.
Zou, J.; Trinh, S.; Erskine, A.; Jing, M.; Yao, J.; Walker, S.; Li, Y.; Hires, S. A.
Show abstract
Numerous cognitive functions including attention and learning are influenced by the dynamic patterns of acetylcholine release across the brain. How acetylcholine mediates these functions in cortex remains unclear, as the relationship between cortical acetylcholine and behavioral events has not been precisely measured across task learning. To dissect this relationship, we quantified motor behavior and sub-second acetylcholine dynamics in primary somatosensory and auditory cortex during rewarded sensory detection and discrimination tasks. We found that acetylcholine dynamics were directly attributable to goal-directed actions (whisker motion and licking), rather than delivery of sensory cues or rewards. As task performance improved across training, acetylcholine release associated with the first lick in a trial was strongly and specifically potentiated. These results show that acetylcholine dynamics in sensory cortex are driven by directed motor actions to gather information and act upon it.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances learning of cue-reward contingency 98%
- Acetylcholine modulates prefrontal outcome coding during threat learning under uncertainty 98%
- Mixed representations of choice direction and outcome by GABA/glutamate cotransmitting neurons in the entopeduncular nucleus 97%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.