Evolutionary traits of Tick-borne encephalitis virus: Pervasive non-coding RNA structure conservation and molecular epidemiology
Kutschera, L. S.; Wolfinger, M. T.
Show abstract
Tick-borne encephalitis virus (TBEV) is the etiological agent of tick-borne encephalitis, an infectious disease of the central nervous system that is often associated with severe sequelae in humans. While TBEV is typically classified into three subtypes, recent evidence suggests a more varied range of TBEV subtypes and lineages that differ substantially in the architecture of their 3 untranslated region (3UTR). Building on comparative genomics approaches and thermodynamic modelling, we characterize the TBEV UTR structureome diversity and propose a unified picture of pervasive non-coding RNA (ncRNA) structure conservation. Moreover, we provide an updated phylogeny of TBEV, building on more than 220 publicly available complete genomes, and investigate the molecular epidemiology and phylodynamics with Nextstrain, a web-based visualization framework for real-time pathogen evolution.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Diving Deep into Fish Bornaviruses: Uncovering Hidden Diversity and Transcriptional Strategies through Comprehensive Data Mining 97%
- Frequent intergenotypic recombination between the non-structural and structural genes is a major driver of epidemiological fitness in caliciviruses 96%
- A phylogenetic contribution to understanding the panzootic spread of African swine fever: from the global to the local scale 96%
Similar papers in this journal
Similar papers in this journal
- The evolutionary and molecular history of a chikungunya virus outbreak lineage 96%
- Population genomics of louping ill virus provide new insights into the evolution of tick-borne flaviviruses 95%
- Viral metagenome characterization reveals species-specific virome profiles in Triatominae populations from the southern United States 94%
Similar papers in this journal
- Deep mining of the Sequence Read Archive reveals bipartite coronavirus genomes and inter-family Spike glycoprotein recombination 97%
- Genomic transfers help to decipher the ancient evolution of filoviruses and interactions with vertebrate hosts 96%
- Emergence and spread of SARS-CoV-2 variants from farmed mink to humans and back during the epidemic in Denmark, June-November 2020. 96%
Similar papers in this journal
- Taxonomic classification methods reveal a new subgenus in the paramyxovirus subfamily Orthoparamyxovirinae 96%
- Two novel flavi-like viruses shed light on the plant infecting koshoviruses 95%
- Emergence in Southern France of a new SARS-CoV-2 variant of probably Cameroonian origin harbouring both substitutions N501Y and E484K in the spike protein 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.