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High-speed, multi-Z confocal microscopy for voltage imaging in densely labeled neuronal populations

Weber, T. D.; Moya, M. V.; Mertz, J.; Economo, M. N.

2021-12-13 neuroscience
10.1101/2021.12.10.472140 bioRxiv
Show abstract

Genetically encoded voltage indicators (GEVIs) hold great promise for monitoring neuronal population activity, but GEVI imaging in dense neuronal populations remains difficult due to a lack of contrast and/or speed. To address this challenge, we developed a novel confocal microscope that allows simultaneous multiplane imaging with high-contrast at near-kHz rates. This approach enables high signal-to-noise ratio voltage imaging in densely labeled populations and minimizes optical crosstalk during concurrent optogenetic photostimulation.

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