Lipidomic analysis of adipose-derived extracellular vesicles reveals their potential as lipid mediators of obesity-associated metabolic complications
Blandin, A.; Hilairet, G.; Ponnaiah, M.; Ducheix, S.; Dugail, I.; Cariou, B.; Lhomme, M.; Le Lay, S.
Show abstract
Adipose extracellular vesicles (AdEV) transport lipids that could participate to the development of obesity-related metabolic dysfunctions. This study aimed to define mice AdEV lipid signature in either healthy or obesity context by a targeted LC-MS/MS approach. Distinct clustering of AdEV and visceral adipose tissue (VAT) lipidomes by principal component analysis reveals specific lipid composition of AdEV compared to source VAT. Comprehensive analysis identifies enrichment of ceramides and phosphatidylglycerols in AdEV compared to VAT in lean conditions. Lipid subspecies commonly enriched in AdEV highlight specific AdEV-lipid sorting. Obesity impacts AdEV lipidome, driving triacylglycerols and sphingomyelins enrichment in obese versus lean conditions. Obese mice AdEV also display elevated phosphatidylglycerols and acid arachidonic subspecies contents highlighting novel biomarkers and/or mediators of metabolic dysfunctions. Our study identifies specific lipid-fingerprints for plasma, VAT and AdEV that are informative of the metabolic status and underline the signaling capacity of lipids transported by AdEV in obesity-associated complications.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The Cholesteryl Ester Transfer Protein (CETP) raises Cholesterol Levels in the Brain and affects Presenilin-mediated Gene Regulation. 95%
- Quantifying acyl-chain diversity in isobaric compound lipids containing monomethyl branched-chain fatty acids 94%
- ABHD4 regulates adipocyte differentiation in vitro but does not affect adipose tissue lipid metabolism in mice 94%
Similar papers in this journal
- Metabolomic and transcriptomic remodeling of bone marrow myeloid cells in response to maternal obesity 95%
- Reducing 14-3-314-3-3ζ expression influences adipocyte maturity and impairs function 94%
- Proteome analysis of human visceral and subcutaneous adipocytes identifies depot-specific heterogeneity at metabolic control points 94%
Similar papers in this journal
- Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice 93%
- Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue. 93%
- Proteasome dysfunction disrupts adipogenesis and induces inflammation via ATF3 93%
Similar papers in this journal
- Defining the Proteomic and Phosphoproteomic Landscape of Circulating Extracellular Vesicles in the Diabetes Spectrum 95%
- Perturbation of transmembrane 6 superfamily member 2 expression alters lipid metabolism in a human liver cell line 93%
- Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High Fat, High Fructose, High Cholesterol Diet Mouse Model 93%
Similar papers in this journal
- Acute joint inflammation induces a sharp increase in the number of synovial fluid EVs and modifies their phospholipid profile 94%
- NPC1L1 inhibition disturbs lipid trafficking and induces large lipid droplet formation in intestinal absorptive epithelial cells 94%
- Human adipocyte differentiation and composition of disease relevant lipids are regulated by miR-221-3p 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.