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Transposon Extermination Reveals Their Adaptive Fitness Contribution

Cranz-Mileva, S.; Reilly, E.; Chalhoub, N.; Patel, R.; Atanassova, T.; Cao, W.; Ellison, C.; Zaratiegui, M.

2021-11-30 genomics
10.1101/2021.11.29.470382 bioRxiv
Show abstract

Transposable Elements are molecular parasites that persist in their host genome by generating new copies to outpace natural selection. Here we measure the parameters governing the copy number dynamics of the fission yeast Tf2 retrotransposons, using experimental and natural populations and a strain where all Tf2 copies are removed. Natural population genomes display active and persistent Tf2 colonies, but in the absence of selection mitotic recombination deletes Tf2 elements at rates that far exceed transposition. We show that Tf2 elements provide a fitness contribution to their host by dynamically rewiring the transcriptional response to metabolic stress. Therefore, Tf2 elements exhibit a mutualistic rather than parasitic behavior toward their host.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.