Orthoformimycin inhibits translation elongation by displacing the A-site tRNA and preventing peptide bond formation
Schedlbauer, A.; Kaminishi, T.; Fabbretti, A.; Milon, P.; Han, X.; Ochoa-Lizarralde, B.; Capuni, R.; Gualerzi, C. O.; Connell, S. R.; Fucini, P.
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The ribosome is a major target for antibiotics owing to its essential cellular role in protein synthesis. Structural analysis of ribosome-antibiotic complexes provides insight into the molecular basis for their inhibitory action and highlights possible avenues to improve their potential or overcome existing resistance mechanisms. Here we use X-ray crystallography and pre-steady state kinetics to detail the inhibitory mechanism of the antimicrobial on the large ribosomal subunit.
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