Convergent evolution of mevalonate pathway in Inonotus obliquus and Betula pendula.
Safronov, O.; Lutfullahoglubal, G.; Sipari, N.; Wilkens, M.; Safdari, P.; Smolander, O.-P.; Lihavainen, J.; Silvan, N.; Rajaraman, S.; Laine, P. K.; Paulin, L.; Auvinen, P.; Sarjala, T.; Overmyer, K.; Kangasjarvi, J.; Battersby, B.; Richter, U.; Salojarvi, J.
Show abstract
Inonotus obliquus, Chaga mushroom, is a fungal species from Hymenochaetaceae family (Basidiomycota) which has been widely used for traditional medicine in Europe and Asia. Here, chaga genome was sequenced using Pacbio sequencing into a 50.7Mbp assembly consisting of 301 primary contigs with an N50 value of 375 kbp. Genome evolution analyses revealed a lineage-specific whole genome duplication event and an expansion of Cytochrome P450 superfamily. Fungal biosynthetic clusters were enriched for tandemly duplicated genes, suggesting that biosynthetic pathway evolution has proceeded through small-scale duplications. Metabolomic fingerprinting confirmed a highly complex terpene biosynthesis chemistry when compared against related fungal species lacking the genome duplication event.
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