Analysis of transcriptional changes associated with pubertal development
Resztak, J.; Choe, J.; Wei, J.; Bruinsma, R.; Houpt, R.; Alazizi, A.; Mair-Meijers, H.; Slatcher, R.; Zilioli, S.; Pique-Regi, R.; Luca, F.
Show abstract
Puberty is an important developmental period marked by hormonal, metabolic and immune changes. Puberty also marks a shift in sex differences in susceptibility to asthma. Yet, little is known about the gene expression changes in immune cells that occur during pubertal development. Here we assess pubertal development and leukocyte gene expression in a longitudinal cohort of 251 children with asthma. We identify substantial gene expression changes associated with age and pubertal development. Gene expression changes between pre- and post-menarcheal females suggest a shift from predominantly innate to adaptive immunity. We show that genetic effects on gene expression change dynamically during pubertal development. Gene expression changes during puberty are correlated with gene expression changes associated with asthma and may explain sex differences in prevalence. Our results show that molecular data used to study the genetics of early onset diseases should consider pubertal development as an important factor that modifies the transcriptome.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The genetic and phenotypic correlates of neonatal Complement Component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders 94%
- Blood-based epigenome-wide analyses of chronic low-grade inflammation across diverse population cohorts 94%
- Early establishment and life course stability of sex biases in the human brain transcriptome 94%
Similar papers in this journal
- The transcriptomic landscape of monosomy X (45,X) during early human fetal and placental development 94%
- Composite trait Mendelian Randomization reveals distinct metabolic and lifestyle consequences of differences in body shape 94%
- Genetic, parental and lifestyle factors influence telomere length 94%
Similar papers in this journal
- Aged mouse ovarian immune milieu shows a shift towards adaptive immunity and attenuated cell function 94%
- 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity 94%
- Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.