Impaired astrocytic Ca2+ signalling in awake Alzheimer's disease transgenic mice
Abjorsbraten, K. S.; Skaaraas, G. H. E. S.; Cunen, C.; Bjornstad, D. M.; Binder, K. M. G.; Jensen, V.; Nilsson, L. N.; Rao, S. B.; Tang, W.; Hermansen, G. H.; Nagelhus, E. A.; Ottersen, O. P.; Torp, R.; Enger, R.
Show abstract
Increased astrocytic Ca2+ signaling related to amyloid plaques has been shown in Alzheimers disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca2+ signalling in such mice without the confounding effects of anesthesia. Here, we employ an event-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake-behaving tg-ArcSwe mice and non-transgenic wildtype littermates while monitoring pupil responses and behavior. We demonstrate an attenuated astrocytic Ca2+ response to locomotion and an uncoupling of pupil responses and astrocytic Ca2+ signalling in 15-months old plaque-bearing mice. This points to a potential decoupling of neuromodulatory activation and astrocytic Ca2+ activity, which may account for some of the cognitive dysfunctions observed in Alzheimers disease.
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