Back
#1
32.6%
Top 50%
13.5%
Top 21%
8.9%
Top 0.4%
4.4%
Top 4%
4.4%
Top 18%
2.2%
Top 7%
2.2%
Top 34%
2.2%
Top 2%
1.5%
Top 17%
1.3%
Top 15%
1.1%
Top 9%
1.1%
Top 5%
0.8%
Top 6%
0.8%
Top 6%
0.8%
Top 12%
0.8%
Top 8%
0.5%
Top 27%
0.5%
Top 70%
0.5%
Top 17%
0.5%
Top 24%
0.5%
Multi-ethnic polygenic risk modifies the association between APOL1 high risk genotypes and chronic kidney disease
2021-11-14
nephrology
Title + abstract only
View on medRxiv
Show abstract
The burden of advanced chronic kidney disease (CKD) falls disproportionately on minorities including African Americans (AAs) and Hispanic Americans (HAs) with admixed ancestry. Even though APOL1 high-risk genotypes increase risk of kidney disease, their penetrance is incomplete, indicating that the modification of APOL1 high risk may be polygenic. For this study, we used three multi-ethnic cohorts with APOL1 high risk genotypes and calculated a multi-ethnic PRS using publicly available summary s...
Predicted journal destinations
1
Journal of the American Society of Nephrology
19 training papers
2
PLOS ONE
1737 training papers
3
Scientific Reports
701 training papers
4
Nature Medicine
88 training papers
5
BMC Medicine
155 training papers
6
eLife
262 training papers
7
Journal of Clinical Medicine
77 training papers
8
Nature Communications
483 training papers
9
Diabetologia
23 training papers
10
JAMA Network Open
125 training papers
11
PLOS Medicine
95 training papers
12
International Journal of Epidemiology
65 training papers
13
Journal of Clinical Investigation
50 training papers
14
Hypertension
20 training papers
15
Communications Medicine
63 training papers
16
Journal of the American Heart Association
92 training papers
17
PLOS Genetics
39 training papers
18
Cureus
64 training papers
19
BMJ Open
553 training papers
20
eBioMedicine
82 training papers
21
Proceedings of the National Academy of Sciences
100 training papers