MICS1 is the Ca2+ /H+ antiporter of mammalian mitochondria
Austin, S.; Mekis, R.; Mohammed, S. E. M.; Scalise, M.; Pfeiffer, C.; Galluccio, M.; Borovec, T.; Parapatics, K.; Vitko, D.; Dinhopl, N.; Bennett, K. L.; Nowikovsky, K.
Show abstract
Mitochondrial Ca2+ ions are crucial regulators of bioenergetics, cell death pathways and cytosolic Ca2+ homeostasis. Mitochondrial Ca2+ content strictly depends on Ca2+ transporters. In recent decades, the major players responsible for mitochondrial Ca2+ uptake and release have been identified, except the mitochondrial Ca2+/H+ exchanger (CHE). Originally identified as the mitochondrial K+/H+ exchanger, LETM1 was also considered as a candidate for the mitochondrial CHE. Defining the mitochondrial interactome of LETM1, we identified MICS1, the only mitochondrial member of the TMBIM family. Applying cell-based and cell-free biochemical assays, here we demonstrate that MICS1 is responsible for the Na+- and permeability transition pore-independent mitochondrial Ca2+ release and identify MICS1 as the long-sought mitochondrial CHE. This finding provides the final piece of the puzzle of mitochondrial Ca2+ transporters and opens the door to exploring its importance in health and disease, and to developing drugs modulating Ca2+ exchange.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Structural and functional properties of a plant NRAMP related aluminum transporter 96%
- CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression 96%
- Skd3 (human CLPB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations 95%
Similar papers in this journal
Similar papers in this journal
- The human MRS2 magnesium binding domain is a regulatory feedback switch for channel activity. 96%
- ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway 95%
- Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2 95%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.