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3D reconstruction of cell nuclei in a full Drosophila brain

Mu, S.; Yu, S.-c.; Turner, N. L.; McKellar, C. E.; Dorkenwald, S.; Collman, F.; Koolman, S.; Moore, M.; Morejohn, S.; Silverman, B.; Willie, K.; Willie, R.; Bland, D.; Burke, A.; Ashwood, Z.; Luther, K.; Castro, M.; Ogedengbe, O.; Silversmith, W.; Wu, J.; Halageri, A.; Macrina, T.; Kemnitz, N.; Murthy, M.; Seung, H. S.

2021-11-04 neuroscience
10.1101/2021.11.04.467197 bioRxiv
Show abstract

We reconstructed all cell nuclei in a 3D image of a Drosophila brain acquired by serial section electron microscopy (EM). The total number of nuclei is approximately 133,000, at least 87% of which belong to neurons. Neuronal nuclei vary from several hundred down to roughly 5 cubic micrometers. Glial nuclei can be even smaller. The optic lobes contain more than two times the number of cells than the central brain. Our nuclear reconstruction serves as a spatial map and index to the cells in a Drosophila brain.

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