Altered expression of Api5 affects breast carcinogenesis by modulating FGF2 signalling
K, A.; Panda, D.; Malaviya, R.; Gaidhani, G.; Lahiri, M.
Show abstract
Apoptosis or programmed cell death plays a vital role in maintaining homeostasis and, therefore, is a tightly regulated process. Deregulation of apoptosis signalling can favour carcinogenesis. Apoptosis inhibitor 5 (Api5), an inhibitor of apoptosis, is upregulated in cancers. Interestingly, Api5 is shown to regulate both apoptosis and cell proliferation. To address the precise functional significance of Api5 in carcinogenesis here we investigate the role of Api5 in breast carcinogenesis. Consistently, in-silico analysis revealed elevated levels of Api5 transcript in breast cancer patients which correlated with poor prognosis. Overexpression of Api5 in non-tumorigenic breast acinar cultures resulted in increased proliferation and cells exhibited a partial EMT-like phenotype with higher migratory potential and disruption in cell polarity. Furthermore, during acini development, the influence of Api5 is mediated via the combined action of FGF2 activated PDK1-Akt/cMYC signalling and Ras-ERK pathways. Conversely, Api5 knock-down downregulated FGF2 signalling leading to reduced proliferation and diminished in vivo tumorigenic potential of the breast cancer cells. Thus, taken together, our study identifies Api5 as a central player involved in regulating multiple events during breast carcinogenesis.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Suppression of Ovarian Cancer Cell Proliferation is Associated with Upregulation of Cell-Matrix Adhesion Programs and Integrin-β4-Induced Cell Protection from Cisplatin. 94%
- Epigenetic Modulation of SPCA2 Reverses Epithelial to Mesenchymal Transition in Breast Cancer Cells 94%
- Protein profiling of breast carcinomas reveals expression of immune-suppressive factors and signatures relevant to patient outcome 94%
Similar papers in this journal
- Promyelocytic Leukemia Protein regulates Angiogenesis and Epithelial-Mesenchymal Transition to limit metastasis in MDA-MB-231 breast cancer cells. 95%
- Targeting LDHC dysregulates the cell cycle and improves sensitivity to cisplatin and olaparib 94%
- Lipocalin 2 promotes inflammatory breast cancer tumorigenesis and skin invasion 94%
Similar papers in this journal
- Stromal NRG1 in luminal breast cancer defines pro-fibrotic and migratory cancer-associated fibroblasts 96%
- Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer 94%
- EGFR amplification and PI3K pathway mutations identify a subset of breast cancers that synergistically respond to EGFR and PI3K inhibition 93%
Similar papers in this journal
- S100A8/A9 mediate the reprograming of normal mammary epithelial cells induced by dynamic cell-cell interactions with adjacent breast cancer cells. 95%
- MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis 95%
- Oncogenic signaling inhibits c-FLIP expression and promotes cancer cell survival during ECM-detachment 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.