Violet light modulates the central nervous system to regulate memory and mood
Sasaki, N.; Gusain, P.; Hayano, M.; Sugaya, T.; Tonegawa, N.; Hatanaka, Y.; Tamura, R.; Okuyama, K.; Osada, H.; Ban, N.; Mitsukura, Y.; Lang, R. A.; Mimura, M.; Tsubota, K.
Show abstract
Light stimuli from the external environment serves as a signal. Photoreceptors receive photons at the outer nuclear layer of the retina. Non-visual photoreceptors, such as opsin5 (also known as OPN5 or neuropsin), are expressed in the retinal ganglion cells (RGCs) and hypothalamus to regulate the circadian cycle and body temperature. Here, we show that violet light (VL) stimuli received by OPN5-positive RGCs are transmitted to the habenula brain region. VL improves memory in aged mice and simultaneously increases neural architecture-related genes such as oligodendrocyte-related genes in the hippocampus. In addition, VL improves depressive-like behaviors in the social defeat stress model in an OPN5 dependent manner. Following VL exposure, cFos activation is observed at the nucleus accumbens (NAc) and the paraventricular thalamic nucleus (PVT). Taken together, the results indicate that violet light modulates brain function such as memory and mood by transmitting the signal from RGCs to the habenula region in the brain.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- YTHDF2 in dentate gyrus is the m6A reader mediating m6A modification in hippocampus-dependent learning and memory 96%
- Serotonin sensing by microglia conditions the proper development of neuronal circuits and of social and adaptive skills 96%
- Long-lived adult-born hippocampal neurons promote successful cognitive aging 96%
Similar papers in this journal
- Age-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG 97%
- SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration 96%
- SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress 96%
Similar papers in this journal
- Assessment of neurobehavioural traits under axenic conditions: an approach for multiple longitudinal analyses in the same mouse. 95%
- Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling 94%
- Sex specific correction of maternal inflammation-induced behavioral abnormalities by the inhibition of colony-stimulating factor 1 receptor 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.