Nucleocapsid antibody positivity as a marker of past SARS-CoV-2 infection in population serosurveillance studies: impact of variant, vaccination, and choice of assay cut-off
Whitaker, H. J.; Gower, C.; Otter, A. D.; Simmons, R.; Kirsebom, F.; Letley, L.; Quinot, C.; Ireland, G.; Linley, E.; Ribeiro, S.; Ladhani, S.; Lopez-Bernal, J.; Amirthalingam, G.; Ramsay, M. E.; Brown, K. E.
Show abstract
Serological surveillance studies sometimes use presence of anti-nucleocapsid antibody as a marker of natural SARS-CoV-2 infection. We explore seroconversion rates and antibody levels following Alpha and Delta variant infections, and vaccine breakthrough infections. We find lower seroconversion rates particularly following Alpha-variant vaccine breakthrough infections. We re-evaluate assay performance with a mix of past waned infections and recent breakthrough infections, that is relevant to current serological surveillance.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Slow waning of antibodies following a third dose of BNT162b2 in adults who had previously received two doses of inactivated vaccine 95%
- SARS-CoV-2 seroassay optimization and performance in a population with high background reactivity in Mali 94%
- Anti-SARS-CoV-2 Antibody Levels Associated with COVID-19 Protection in Outpatients Tested for SARS-CoV-2, US Flu VE Network, October 2021–June 2022 93%
Similar papers in this journal
- Validity of self-testing at home with rapid SARS-CoV-2 antibody detection by lateral flow immunoassay 96%
- The New Normal: Delayed Peak SARS-CoV-2 Viral Loads Relative to Symptom Onset and Implications for COVID-19 Testing Programs 94%
- Single-dose mRNA vaccine effectiveness against SARS-CoV-2, including P.1 and B.1.1.7 variants: a test-negative design in adults 70 years and older in British Columbia, Canada 94%
Similar papers in this journal
- The performance of the SARS-CoV-2 RT-PCR test as a tool for detecting SARS-CoV-2 infection in the population: A survey of routine laboratory RT-PCR test results from the region of Münster, Germany 94%
- Protection of vaccine boosters and prior infection against mild/asymptomatic and moderate COVID-19 infection in the UK SIREN healthcare worker cohort: October 2023 to March 2024 94%
- Emergence of SARS-CoV-2 Alpha (B.1.1.7) variant, infection rates, antibody seroconversion and seroprevalence rates in secondary school students and staff: active prospective surveillance, December 2020 to March 2021, England 93%
Similar papers in this journal
- Dynamic change and clinical relevance of post-infectious SARS-CoV-2 antibody responses 95%
- Evaluation of six commercial SARS-CoV-2 Enzyme-Linked Immunosorbent assays for clinical testing and serosurveillance 95%
- Strong neutralizing antibody responses to SARS-CoV-2 variants following a single vaccine dose in subjects with previous SARS-CoV-2 infection 94%
Similar papers in this journal
- Impact of age, gender, ethnicity and prior disease status on immunogenicity following administration of a single dose of the BNT162b2 mRNA Covid-19 Vaccine: real-world evidence from Israeli healthcare workers, December-January 2020 93%
- Estimating the false-negative test probability of SARS-CoV-2 by RT-PCR 93%
- Seroprevalence of antibodies against SARS-CoV-2 virus in the adult Norwegian population, winter 2020/2021: pre-vaccination period 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.