SARS-CoV-2 infects human adipose tissue and elicits an inflammatory response consistent with severe COVID-19
Martinez-Colon, G. J.; Ratnasiri, K.; Chen, H.; Jiang, S.; Zanley, E.; Rustagi, A.; Verma, R.; Chen, H.; Andrews, J. R.; Mertz, K.; Tzankov, A.; Azagury, D.; Boyd, J.; Nolan, G. P.; Schürch, C. M.; Matter, M. S.; Blish, C. A.; McLaughlin, T. L.
Show abstract
The COVID-19 pandemic, caused by the viral pathogen SARS-CoV-2, has taken the lives of millions of individuals around the world. Obesity is associated with adverse COVID-19 outcomes, but the underlying mechanism is unknown. In this report, we demonstrate that human adipose tissue from multiple depots is permissive to SARS-CoV-2 infection and that infection elicits an inflammatory response, including the secretion of known inflammatory mediators of severe COVID-19. We identify two cellular targets of SARS-CoV-2 infection in adipose tissue: mature adipocytes and adipose tissue macrophages. Adipose tissue macrophage infection is largely restricted to a highly inflammatory subpopulation of macrophages, present at baseline, that is further activated in response to SARS-CoV-2 infection. Preadipocytes, while not infected, adopt a proinflammatory phenotype. We further demonstrate that SARS-CoV-2 RNA is detectable in adipocytes in COVID-19 autopsy cases and is associated with an inflammatory infiltrate. Collectively, our findings indicate that adipose tissue supports SARS-CoV-2 infection and pathogenic inflammation and may explain the link between obesity and severe COVID-19. One sentence summaryOur work provides the first in vivo evidence of SARS-CoV-2 infection in human adipose tissue and describes the associated inflammation.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- mRNA-1273 vaccination protects against SARS-CoV-2 elicited lung inflammation in non-human primates 94%
- Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice 94%
- Balance between maternal antiviral response and placental transfer of protection in gestational SARS-CoV-2 infection 94%
Similar papers in this journal
- Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory programming and continual clearance of apoptotic cells 95%
- Mitochondrial respiration contributes to the interferon gamma response in antigen presenting cells 95%
- Impact of pregravid obesity on anti-microbial fetal monocyte response 95%
Similar papers in this journal
- Heterogeneity of monocyte subsets and susceptibility to influenza virus contribute to inter-population variability of protective immunity 94%
- Transcriptional, epigenetic, and functional reprogramming of blood monocytes in non-human primates following chronic alcohol drinking 94%
- ScRNA-Seq study of neutrophils reveals vast heterogeneity and breadth of inflammatory responses in severe COVID-19 patients 94%
Similar papers in this journal
- Human nasal and lung tissues infected ex vivo with SARS-CoV-2 provide insights into differential tissue-specific and virus-specific innate immune responses in the upper and lower respiratory tract 94%
- ILRUN downregulates ACE2 expression and blocks infection of human cells by SARS-CoV-2 94%
- Cellular heterogeneity and molecular reprogramming of host response during influenza acute lung injury 94%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.