Rare modification in the ergosterol biosynthesis pathway leads to amphotericin B resistance in Candida auris clinical isolates
Kordalewska, M.; Guerrero, K. D.; Mikulski, T. D.; Elias, T. N.; Garcia-Rubio, R.; Berrio, I.; Gardam, D.; Heath, C. H.; Chowdhary, A.; Govender, N. P.; Perlin, D. S.
Show abstract
We determined amphotericin B (AmB) susceptibility and sequenced key genes of the ergosterol biosynthesis pathway implicated in AmB resistance (ERG2, ERG3, ERG6, ERG11) of 321 clinical isolates of Candida auris. In antifungal susceptibility testing, 19 (5.9%) isolates were categorized as AmB-resistant (MIC [≥]2 mg/l). Only one AmB-resistant isolate presented a unique non-wild-type ERG6 genotype that was confirmed to confer amphotericin B resistance (MIC >32 mg/l) when introduced into a susceptible strain (MIC = 0.5 mg/l).
Matching journals
The top 1 journal accounts for 50% of the predicted probability mass.
Similar papers in this journal
- Evaluation of in vitro activity of manogepix against multidrug-resistant and pan-resistant Candida auris from the New York Outbreak 98%
- In vitro Evaluation of Antifungal Drug Combinations against Multidrug-resistant Candida auris isolates from New York Outbreak 97%
- Impact of Erg11 amino acid substitutions identified in Candida auris clade III isolates on triazole drug susceptibility 97%
Similar papers in this journal
- CanID-PCR: A quick and low-cost PCR tool to identify Candida species on gDNA directly extracted from positive blood bottles 94%
- Differential growth rates and in vitro drug susceptibility to currently used drugs for multiple isolates of Naegleria fowleri 94%
- Mutations in ampD cause hyperproduction of AmpC and CphA beta-lactamases and high resistance to beta-lactam antibiotics in Chromobacterium violaceum 93%
Similar papers in this journal
- Functional characterization of clinical isolates of the opportunistic fungal pathogen Aspergillus nidulans 95%
- Bisphosphonates synergistically enhance the antifungal activity of azoles in dermatophytes and other pathogenic molds 95%
- Transcriptional profiling of the Candida auris response to exogenous farnesol exposure 93%
Similar papers in this journal
- Genome-wide analysis of experimentally evolved Candida auris reveals multiple novel mechanisms of multidrug-resistance 98%
- Mutations in TAC1B: a novel genetic determinant of clinical fluconazole resistance in C. auris 96%
- Development of Candida auris microsatellite typing and its application on a global collection of isolates 95%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.