Characterisation of the phase-variable autotransporter Lav reveals a role in host cell adherence and biofilm formation in Non-Typeable Haemophilus influenzae
Phillips, Z. N.; Garai, P.; Tram, G.; Husna, A.-U.; Staples, M.; Grimwood, K.; Jennison, A.; Jennings, M. P.; Brockman, K.; Atack, J. M.
Show abstract
Lav is an autotransporter protein found in pathogenic Haemophilus and Neisseria species. Lav in non-typeable Haemophilus influenzae (NTHi) is phase-variable: the gene reversibly switches ON-OFF via changes in length of a locus-located GCAA(n) simple DNA sequence repeat tract. The expression status of lav was examined in carriage and invasive collections of NTHi, where it was predominantly not expressed (OFF). Phenotypic study showed lav expression (ON) results in increased adherence to host cells, and denser biofilm formation. A survey of Haemophilus spp. genome sequences showed lav is present in [~]60% of NTHi strains, but lav is not present in most typeable H. influenzae. Sequence analysis revealed a total of five distinct variants of the Lav passenger domain present in Haemophilus spp., with these five variants showing a distinct lineage distribution. Determining the role of Lav in NTHi will help understand the role of this protein during distinct pathologies.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Achromobacter xylosoxidans isolates exhibit genome diversity, variable virulence, high levels of antibiotic resistance and potential intrahost evolution. 96%
- A novel conserved protein in Streptococcus agalactiae, BvaP, is important for vaginal colonization and biofilm formation 96%
- The small RNA ErsA plays a role in the regulatory network of Pseudomonas aeruginosa pathogenicity in airways infection 95%
Similar papers in this journal
- Gentamicin induction of the gonococcal hicAB toxin-antitoxin encoding system and 2 impact on gene expression influencing biofilm formation and in vivo fitness in a strain specific manner 96%
- NirA is an alternative nitrite reductase from Pseudomonas aeruginosa with potential as an anti-virulence target 95%
- The non-typeable Haemophilus influenzae major adhesin Hia is a dual function lectin that binds to human-specific respiratory tract sialic acid glycan receptors. 95%
Similar papers in this journal
- Limited adaptive evolution of Staphylococcus aureus during transition from colonization to invasive infection 95%
- Pseudomonas aeruginosa promotes persistence of Stenotrophomonas maltophilia via increased adherence to depolarized respiratory epithelium 95%
- Comparative Characterization Reveals Conserved and Divergent Ecological Traits of Oral Corynebacteria 94%
Similar papers in this journal
- The two-component system YesMN promotes pneumococcal host-to-host transmission, and regulates genes involved in zinc homeostasis 95%
- Assessing the role of cold-shock protein C: A novel regulator of Acinetobacter baumannii biofilm formation and virulence 95%
- Simulated colonic fluid replicates the in vivo growth capabilities of Citrobacter rodentium cpxRA mutants and uncovers additive effects of Cpx regulated genes on fitness 94%
Similar papers in this journal
- Interplay of Virulence Factors and Signaling Molecules: Albumin and Calcium-Mediated Biofilm Regulation in Bordetella bronchiseptica 95%
- Conserved FimK truncation coincides with increased expression of type 3 fimbriae and cultured bladder epithelial cell association in Klebsiella quasipneumoniae 95%
- Serotype specific sugars impact structure but not functions of the trimeric autotransporter adhesin EmaA of Aggregatibacter actinomycetemcomitans. 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.