Genome-wide association study identifies new locus associated with OCD
Strom, N. I.; Yu, D.; Gerring, Z. F.; Halvorsen, M. W.; Abdellaoui, A.; Rodriguez-Fontenla, C.; Sealock, J. M.; Bigdeli, T.; Coleman, J. R. I.; Mahjani, B.; Thorp, J. G.; Bey, K.; Burton, C. L.; Luykx, J. J.; Zai, G.; Askland, K. D.; Barlassina, C.; Becker Nissen, J.; Bellodi, L.; Bienvenu, O. J.; Black, D.; Bloch, M.; Boberg, J.; Bosch, R.; Breen, M.; Brennan, B. P.; Brentani, H.; Buxbaum, J. D.; Bybjerg-Grauholm, J.; Byrne, E. M.; Camarena, B.; Camarena, A.; Cappi, C.; Carracedo, A.; Casas, M.; Cavallini, M. C.; Ciullo, V.; Cook, E. H.; Coric, V.; Cullen, B. A.; De Schipper, E. J.; Devlin, B
Show abstract
Obsessive-compulsive disorder (OCD) is a heritable disorder, but no definitive, replicated OCD susceptibility loci have yet been identified by any genome-wide association study (GWAS). Here, we report results from a GWAS in the largest OCD case-control sample (N = 14,140 OCD cases and N = 562,117 controls) to date. We explored the genetic architecture of OCD, including its genetic relationships to other psychiatric and non-psychiatric phenotypes. In the GWAS analysis, we identified one SNP associated with OCD at a genome-wide significant level. Subsequent gene-based analyses identified additional two genes as potentially implicated in OCD pathogenesis. All SNPs combined explained 16% of the heritability of OCD. We show sub-stantial positive genetic correlations between OCD and a range of psychiatric disorders, including anxiety disorders, anorexia nervosa, and major depression. We thus for the first time provide evidence of a genome-wide locus implicated in OCD and strengthen previous literature suggesting a polygenic nature of this disorder.
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