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Antibacterial 3D-printed PMMA/ceramic composites

Marin, E.; Mukai, M.; Boschetto, F.; Sunthar, T. P. M.; Adachi, T.; Zhu, W.; Rondinella, A.; Lanzutti, A.; Kanamura, N.; Yamamoto, T.; Fedrizzi, L.; Pezzotti, G.

2021-10-12 bioengineering
10.1101/2021.10.11.463892 bioRxiv
Show abstract

Following the rising interested on 3D-printed technologies, this research explores the possibility to use stereo-lithography to 3D print PMMA resins reinforced with up to 15% in weight of antibacterial ceramic powders. Three different reinforcements were tested, following previous literature data: aluminum nitride, titanium oxide and barium titanate. Between the three powders, the most uniform dispersion was achieved using aluminum nitride. Initial screenings with mixed and cured composite resins showed that between the three composite materials, only aluminum nitride or barium titanate PMMA showed a clear antibacterial effect when compared to the pristine reference, with aluminum nitride being the most effective against E. coli. When 3D printed using stereo-lithography, the composite containing aluminum nitride showed an even higher degree of dispersion and comparable antibacterial effects. Moreover, aluminum nitride reinforced PMMA resins showed good mechanical properties, comparable to the basic resin, and could be further strengthened by a standard post-curing process.

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