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A sensitive and specific genetically encodable biosensor for potassium ions

Wu, S.-Y.; Wen, Y.; Serre, N. B. C.; Laursen, C. C. H.; Dietz, A. G.; Taylor, B. R.; Aggarwal, A.; Rancic, V.; Becker, M.; Ballanyi, K.; Podgorski, K.; Hirase, H.; Nedergaard, M.; Fendrych, M.; Lemieux, M. J.; Eberl, D. F.; Kay, A. R.; Campbell, R. E.; Shen, Y.

2021-10-09 bioengineering
10.1101/2021.10.07.463410 bioRxiv
Show abstract

Potassium ions (K+) play a critical role as an essential electrolyte in all biological systems. Here we report the crystal structure-guided optimization and directed evolution of an improved genetically encoded fluorescent K+ biosensor, GINKO2. GINKO2 is highly sensitive and specific for K+ and enables in vivo detection of K+ dynamics in multiple species.

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