Mapping the functional interactions at the tumor-immune checkpoint interface
Bozorgui, B.; Kong, E. K.; Luna, A.; Korkut, A.
Show abstract
It is challenging to identify the tumor-immune system interactions that modulate immune states and immunotherapy responses due to the prohibitively complex space of possible interactions. Our statistical analysis framework, ImogiMap quantifies tumor-immune interactions based on their synergistic co-associations with immune-associated phenotypes. ImogiMap-based analyses recapitulated known interactions modulating immunotherapy responses and nominated the CD86/CD70 axis as an immunotherapy target that overlaps with IFNG overexpression and patient survival in endometrial carcinoma.
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