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Power dynamics of theta oscillations during goal-directed navigation in freely moving humans: A mobile EEG-virtual reality T-maze study

Lin, M.-h.; Liran, O.; Bauer, N. K.; Baker, T. E.

2021-10-07 neuroscience
10.1101/2021.10.05.463245 bioRxiv
Show abstract

Theta oscillations ([~]4-12 Hz) are dynamically modulated by speed and direction in freely moving animals. However, due to the paucity of electrophysiological recordings of freely moving humans, this mechanism remains poorly understood. Here, we combined mobile-EEG with fully immersive virtual-reality to investigate theta dynamics in twenty-two healthy adults (aged 18-29 years old) freely navigating a T-maze to find rewards. Our results revealed three dynamic periods of theta modulation: 1) theta power increases coincided with the participants decision-making period; 2) theta power increased for fast and leftward trials as subjects approached the goal location; and 3) feedback onset evoked two phase-locked theta bursts over the right temporal and frontal-midline channels. These results suggest that recording scalp EEG in freely moving humans navigating a simple virtual T-maze can be utilized as a powerful translational model by which to map theta dynamics during "real-life" goal-directed behavior in both health and disease.

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