Acute COVID-19 gene-expression profiles show multiple etiologies of long-term sequelae
Thompson, R. C.; Simons, N. W.; Wilkins, L.; Cheng, E.; Del-Valle, D. M.; Hoffman, G. E.; Fennessy, B.; Mouskas, K.; Francoeur, N. J.; Johnson, J. S.; Lepow, L.; Le Berichel, J.; Chang, C.; Beckmann, A. G.; Wang, Y.-c.; Nie, K.; Zaki, N.; Tuballes, K.; Barcessat, V.; Cedillo, M. A.; Huckins, L.; Roussos, P.; Marron, T. U.; The Mount Sinai COVID-19 Biobank Team, ; Glicksberg, B. S.; Nadkarni, G.; Gonzalez-Kozlova, E.; Kim-Schulze, S.; Sebra, R.; Merad, M.; Gnjatic, S.; Schadt, E. E.; Charney, A. W.; Beckmann, N. D.
Show abstract
Summary ParagraphTwo years into the SARS-CoV-2 pandemic, the post-acute sequelae of infection are compounding the global health crisis. Often debilitating, these sequelae are clinically heterogeneous and of unknown molecular etiology. Here, a transcriptome-wide investigation of this new condition was performed in a large cohort of acutely infected patients followed clinically into the post-acute period. Gene expression signatures of post-acute sequelae were already present in whole blood during the acute phase of infection, with both innate and adaptive immune cells involved. Plasma cells stood out as driving at least two distinct clusters of sequelae, one largely dependent on circulating antibodies against the SARS-CoV-2 spike protein and the other antibody-independent. Altogether, multiple etiologies of post-acute sequelae were found concomitant with SARS-CoV-2 infection, directly linking the emergence of these sequelae with the host response to the virus.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Immunity in Omicron SARS-CoV-2 breakthrough COVID-19 in vaccinated adults 96%
- Mechanisms of Epigenomic and Functional Convergence Between Glucocorticoid and IL4-Driven Macrophage Programming 96%
- Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19 96%
Similar papers in this journal
Similar papers in this journal
- The cellular immune response to COVID-19 deciphered by single cell multi-omics across three UK centres 97%
- Combined landscape of single-nucleotide variants and copy-number alterations in clonal hematopoiesis 96%
- An Immune Cell Atlas Reveals Dynamic COVID-19 Specific Neutrophil Programming Amenable to Dexamethasone Therapy 95%
Similar papers in this journal
- Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity 95%
- Functional proteomic profiling links deficient DNA clearance to mortality in patients with severe COVID-19 pneumonia 95%
- Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Transcriptional and Biochemical Function 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.