Microglia mediate synaptic plasticity induced by 10 Hz repetitive magnetic stimulation
Eichler, A.; Kleidonas, D.; Turi, Z.; Kirsch, M.; Pfeifer, D.; Masuda, T.; Prinz, M.; Lenz, M.; Vlachos, A.
Show abstract
Microglia--the resident immune cells of the central nervous system--sense the activity of neurons and regulate physiological brain functions. They have been implicated in the pathology of brain diseases associated with alterations in neural excitability and plasticity. However, experimental and therapeutic approaches that modulate microglia function in a brain-region-specific manner have not been established. In this study, we tested for the effects of repetitive transcranial magnetic stimulation (rTMS), a clinically employed non-invasive brain stimulation technique, on microglia-mediated synaptic plasticity. 10 Hz electromagnetic stimulation triggered a release of plasticity-promoting cytokines from the microglia in organotypic brain tissue cultures, while no changes in microglial morphology or microglia dynamics were observed. Indeed, substitution of tumor necrosis factor alpha (TNF) and interleukin 6 (IL6) preserved synaptic plasticity induced by 10 Hz stimulation in the absence of microglia. Consistent with these findings, in vivo depletion of microglia abolished rTMS-induced changes in neurotransmission in the medial prefrontal cortex (mPFC) of anesthetized mice. We conclude that rTMS affects neural excitability and plasticity by modulating the release of cytokines from microglia.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- MicroRNA-218 instructs proper assembly of hippocampal networks 95%
- Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum 95%
- REV-ERBalpha mediates complement expression and circadian regulation of microglial synaptic phagocytosis 95%
Similar papers in this journal
- Analysis of microglial BDNF function and expression in the motor cortex 96%
- Dopaminergic neuromodulation of spike timing dependent plasticity in mature adult rodent and human cortical neurons 95%
- Astrocyte gap junctions and Kir channels contribute to K+ buffering and regulate neuronal excitability 94%
Similar papers in this journal
Similar papers in this journal
- Autoimmune inflammation triggers aberrant astrocytic calcium signaling to impair synaptic plasticity 96%
- A Novel Tmem119-tdTomato Reporter Mouse Model for Studying Microglia in the Central Nervous System 95%
- Instability of excitatory synapses in experimental autoimmune encephalomyelitis and the outcome for excitatory circuit inputs to individual cortical neurons 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.