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Reconstructing Sample-Specific Networks using LIONESS

Kuijjer, M. L.; Glass, K.

2021-09-28 systems biology
10.1101/2021.09.27.461954 bioRxiv
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We recently developed LIONESS, a method to estimate sample-specific networks based on the output of an aggregate network reconstruction approach. In this manuscript, we describe how to apply LIONESS to different network reconstruction algorithms and data types. We highlight how decisions related to data preprocessing may affect the output networks, discuss expected outcomes, and give examples of how to analyze and compare single sample networks.

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