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Efficacy of two doses of COVID-19 vaccine against severe COVID-19 in those with risk conditions and residual risk to the clinically extremely vulnerable: the REACT-SCOT case-control study

2021-09-16 epidemiology Title + abstract only
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ObjectivesTo determine whether COVID-19 efficacy varies with clinical risk category and to investigate risk factors for severe COVID-19 in those who have received two doses of vaccine. DesignMatched case-control study (REACT-SCOT). SettingPopulation of Scotland from 1 December 2020 to 8 September 2021. Main outcome measureSevere COVID-19, defined as cases with entry to critical care or fatal outcome. ResultsEfficacy against severe COVID-19 of two doses of vaccine was 94% (95 percent CI 93% t...

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