Brain-Derived Neurotrophic Factor In An Orbitofrontal Cortical-Dorsolateral Striatal Circuit Gates Alcohol Consumption
Moffat, J. J.; Sakhai, S. A.; Ehinger, Y.; Phamluong, K.; Ron, D.
Show abstract
Brain-derived neurotrophic factor (BDNF) signaling in the dorsolateral striatum (DLS) gates alcohol self-administration in rodents. The major source of BDNF in the striatum is the cortex, and we recently found that BDNF-expressing neurons in the ventrolateral orbitofrontal cortex (vlOFC) extend axonal projections to the DLS. We therefore hypothesized that BDNF in the vlOFC to DLS circuit moderates alcohol intake. We show that overexpression of BDNF in the vlOFC, which activates BDNF signaling in the DLS, is sufficient to attenuate voluntary consumption and seeking of 20% alcohol in the home cage using a two-bottle choice paradigm. Overexpressing BDNF in the vlOFC had no effect on the consumption of a sweetened saccharin solution. In addition, BDNF overexpression in the neighboring motor cortex did not alter alcohol intake. Finally, pathway-specific overexpression of BDNF in DLS-projecting vlOFC neurons significantly reduced alcohol intake and preference. Overall, BDNF in the vlOFC, and specifically in a vlOFC-DLS pathway, keeps alcohol drinking in moderation.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Disentangling the effects of Corticotrophin Releasing Factor and GABA release from the ventral bed nucleus of the stria terminalis on ethanol self-administration in mice 95%
- cAMP-Fyn signaling in the dorsomedial striatum direct pathway drives excessive alcohol use 95%
- Histone H3 dopaminylation in ventral tegmental area underlies heroin-induced maladaptive plasticity 95%
Similar papers in this journal
- Lateral hypothalamus CRFR1 regulation of chronic binge drinking: divergence along anterior-posterior axis 96%
- Acute and chronic alcohol modulation of extended amygdala calcium dynamics 96%
- Dynamic regulation of CeA gene expression during acute and protracted abstinence from chronic binge drinking of male and female C57BL/6J mice. 94%
Similar papers in this journal
- Ethanol's interaction with BK channel α subunit residue K361 does not mediate behavioral responses to alcohol in mice 96%
- Kappa Opioid Receptor and Dynorphin Signaling in the Central Amygdala Regulates Alcohol Intake 96%
- Hypodopaminergic state of the nigrostriatal pathway drives compulsive alcohol use 95%
Similar papers in this journal
- Alcohol dependence activates ventral tegmental area projections to central amygdala in male mice and rats 96%
- Chemogenetic Inhibition of Corticostriatal Circuits Reduces Cued Reinstatement of Methamphetamine Seeking 94%
- Dopamine neurons gate the intersection of cocaine use, decision making, and impulsivity 94%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.