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Flexible Path Planning through Vicarious Trial and Error

Krichmar, J. L.; Ketz, N. A.; Pilly, P. K.; Soltoggio, A.

2021-09-09 neuroscience
10.1101/2021.09.08.459317 bioRxiv
Show abstract

AO_SCPLOWBSTRACTC_SCPLOWFlexible planning is necessary for reaching goals and adapting when conditions change. We introduce a biologically plausible path planning model that learns its environment, rapidly adapts to change, and plans efficient routes to goals. Unlike prior models of hippocampal replay, our model addresses the decision-making process when faced with uncertainty. We tested the model in simulations of human and rodent navigation in mazes. Like the human and rat, the model was able to generate novel shortcuts, and take detours when familiar routes were blocked. Similar to rodent hippocampus recordings, the neural activity of the model resembles neural correlates of Vicarious Trial and Error (VTE) during early learning or during uncertain conditions. Similar to rodent studies, after learning, the neural activity resembles forward replay or preplay predicting a future route, and VTE activity decreases. We suggest that VTE, in addition to weighing possible outcomes, is a way in which an organism may gather information for future use.

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