Spinal reconsolidation engages non-ionotropic NMDA receptor signaling to reverse pain hypersensitivity
D'Souza, A. J.; Rodriguez-Hernandez, D.; Zhang, H.; He, D.; Zain, M.; Fung, S.; Bennett, L. A.; Bonin, R. P.
Show abstract
Reconsolidation enables the activity-dependent modification of memory traces and has been used to reverse addiction, fear memory, and pain hypersensitivity in animal models. We demonstrate that non-ionotropic NMDA receptor signalling in the spinal dorsal horn is sufficient to reverse pain hypersensitivity and necessary for pain modulation by spinal reconsolidation. These findings reveal a key process by which reconsolidation disrupts memory traces that may be exploited in the treatment of pain and other disorders.
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