Caspase-mediated nuclear pore complex trimming in cell differentiation and endoplasmic reticulum stress
Cho, U. H.; Hetzer, M. W.
Show abstract
AbstractDuring apoptosis, caspases degrade 8 out of [~]30 nucleoporins to irreversibly demolish the nuclear pore complex. However, for poorly understood reasons, caspases are also activated during cell differentiation. Here, we show that sublethal activation of caspases during myogenesis results in the transient proteolysis of four peripheral Nups and one transmembrane Nup. "Trimmed" NPCs become nuclear export-defective, and we identified in an unbiased manner several classes of cytoplasmic, plasma-membrane, and mitochondrial proteins that rapidly accumulate in the nucleus. NPC trimming by non-apoptotic caspases was also observed in neurogenesis and endoplasmic reticulum stress. Our results suggest that caspases can reversibly modulate nuclear transport activity, which allows them to function as agents of cell differentiation and adaptation at sublethal levels.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- CTCF and transcription influence chromatin structure re-configuration after mitosis 98%
- Allele-resolved single-cell multi-omics uncovers the dynamics and transcriptional kinetics of X-chromosome upregulation 98%
- A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A 98%
Similar papers in this journal
- linc-mipep and linc-wrb encode micropeptides that regulate chromatin accessibility in vertebrate-specific neural cells 98%
- Slowly evolving dopaminergic activity modulates the moment-to-moment probability of movement initiation. 98%
- Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation 98%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.