Bryophyte spermiogenesis occurs through multimode autophagic and nonautophagic degradation
Norizuki, T.; Minamino, N.; Tsukaya, H.; Ueda, T.
Show abstract
Mitochondria change their morphology in response to developmental and environmental cues. During sexual reproduction, bryophytes produce spermatozoids with two mitochondria in the cell body. Although intensive morphological analyses have been conducted thus far, how this fixed number of mitochondria is realized remains unknown. Here, we investigated how mitochondria are reorganized during spermiogenesis in Marchantia polymorpha. We found that the mitochondrial number is reduced to one through fission followed by autophagic degradation during early spermiogenesis, and then the posterior mitochondrion arises by fission of the anterior mitochondrion. Autophagy is also responsible for the removal of other organelles, including peroxisomes, but these other organelles are removed at distinct developmental stages from mitochondrial degradation. We also found that spermiogenesis involves nonautophagic organelle degradation. Our findings highlight the dynamic reorganization of mitochondria, which is regulated distinctly from that of other organelles, and multiple degradation mechanisms operate in organelle remodeling during spermiogenesis in M. polymorpha.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Differential modifications of the C-terminal tails of α-tubulin isoforms and their importance for kinesin-based microtubule transport in vivo 95%
- Phosphorylation of luminal region of the SUN-domain protein Mps3 promotes nuclear envelope localization during meiosis 94%
- FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility 94%
Similar papers in this journal
- The sperm protein SPACA4 is required for efficient fertilization in mice 92%
- POLArIS, a versatile probe for molecular orientation, revealed actin filaments associated with microtubule asters in early embryos 92%
- ISWI chromatin remodeler SMARCA5 is essential for meiotic gene expression and male fertility in mammals 92%
Similar papers in this journal
- Remodeling of organelles and microtubules during spermiogenesis in the liverwort Marchantia polymorpha 98%
- CFAP61 is required for sperm flagellum formation and male fertility in human and mouse 94%
- The intrinsically disordered protein SPE-18 promotes localized assembly of the major sperm protein in C. elegans spermatocytes 94%
Similar papers in this journal
- Nanoscale indentation of plasma membrane establishes a contractile actomyosin scaffold through selective activation of the Amphiphysin-Rho1-Dia/DAAM and Rok pathway 95%
- YTHDC2 Is Essential for Pachytene Progression and Prevents Aberrant Microtubule-Driven Telomere Clustering in Male Meiosis 94%
- ER exit sites in Drosophila display abundant ER-Golgi vesicles and pearled tubes but no megacarriers 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.