In vitro reconstitution demonstrates the amyloid-beta mediated myelin membrane deformation
Saleem, M.; Tiwari, A.; Pradhan, S.; Sannigrahi, A.; Jha, S.; Chattopadhyay, K.; Biswas, M.
Show abstract
Amyloid-beta (A{beta}) aggregation mediated neuronal membrane deformation, although poorly understood, is implicated in Alzheimers Disease (AD). Particularly, whether A{beta} aggregation can induce neuronal demyelination remains unknown. Here we show that A{beta}-40 binds and induces extensive tubulation in the myelin membrane in vitro. The binding of A{beta}-40 depends predominantly on the lipid packing defect densities and electrostatic interactions and results in rigidification of the myelin membrane in the early time scales. Furthermore, elongation of A{beta}-40 into higher oligomeric and fibrillar species leads to eventual fluidization of the myelin membrane followed by extensive membrane tubulation observed in the late phase. Taken together, our results capture mechanistic insights into snapshots of temporal dynamics of A{beta}-40 - myelin membrane interaction and demonstrate how short timescale, local phenomena of binding, and fibril mediated load generation manifests into long timescale, global phenomena of myelin tubulation and demonstrates the ability of A{beta}-40 to demyelinate.
Matching journals
The top 11 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- The cytoplasmic tail of myelin protein zero induces morphological changes in lipid membranes 96%
- Long acyl chain ceramides govern cholesterol and cytoskeleton dependence of membrane outer leaflet dynamics 95%
- Spontaneous transfer of small peripheral peptides between supported lipid bilayer and giant unilamellar vesicles 95%
Similar papers in this journal
- Lipid-induced polymorphic amyloid fibrils formation by α-synuclein. 95%
- Membrane binding of a cyanobacterial ESCRT-III protein crucially involves the helix α1-3 hairpin conserved in all superfamily members 95%
- Differential Effects of Ganglioside Lipids on the Conformation and Aggregation of Islet Amyloid Polypeptide 94%
Similar papers in this journal
- Effect of Cholesterol on Membrane Partitioning Dynamics of Hepatitis A Virus-2B peptide 95%
- Assessing the Extent of Structural and Dynamic Modulation of Membrane Lipids due to Pore Forming Toxins: Insights from Molecular Dynamics Simulations 94%
- Annexin A4 trimers are recruited by high membrane curvatures in Giant Plasma Membrane Vesicles 94%
Similar papers in this journal
- SARS-CoV-2 Fusion Peptide has a Greater Membrane Perturbating Effect than SARS-CoV with Highly Specific Dependence on Ca2+ 95%
- Conformational clamping by a membrane ligand activates the EphA2 receptor 93%
- Activation of Cytochrome C Peroxidase Function Through Coordinated Foldon Loop Dynamics upon Interaction with Anionic Lipids 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.