Evaluation Of The Rims2 Locus As A Risk Locus For Parkinson's Disease Dementia

In their recent letter entitled "Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in parkinsons disease", Liu and colleagues report that in a genome-wide analysis of progression to dementia in parkinsons disease (PD) the RIMS2 locus is a determinant of dementia in PD (1). In this study we have evaluated the nominated loci in a well-powered longitudinal clinical-genetic study of 2536 individuals in the tracking parkinsons and oxford discovery cohorts. We have not identified any association between the RIMS2 locus or other loci from the discovery phase and the development of Parkinsons dementia. further work is needed to understand the biological determinants of this important aspect of parkinsons and to guide the search for new treatments. Brief paragraph/AbstractIn their recent letter entitled "Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinsons disease", Liu and colleagues report that in a genome-wide analysis of progression to dementia in Parkinsons disease (PD) the RIMS2 locus is a determinant of dementia in PD (1). In this study we have evaluated the nominated loci in a well-powered longitudinal clinical-genetic study of 2536 individuals in the Tracking Parkinsons and Oxford Discovery cohorts. We have not identified any association between the RIMS2 locus or other loci from the discovery phase and the development of Parkinsons dementia. Further work is needed to understand the biological determinants of this important aspect of Parkinsons and to guide the search for new treatments.