Characterization of SARS CoV-2 Antibodies in Breast Milk from 21 Women with Confirmed COVID-19 Infection
Bode, L.; Bertrand, K.; Najera, J. A.; Furst, A.; Honerkamp-Smith, G.; Shandling, A. D.; Chambers, C.; Camerini, D.; Campo, J. J.
Show abstract
One potential mechanism for protection from SARS-CoV-2 in infants and young children is through passive immunity via breast milk from a mother previously infected with the novel coronavirus. The primary objectives of this study were to establish the presence of SARS-CoV-2 specific IgA and IgG and to characterize the specific antigenic regions of SARS-CoV-2 proteins that were reactive with antibodies in breast milk from women with confirmed SARS-CoV-2 infection. Between March 2020 and September 2020, 21 women with confirmed SARS-CoV-2 infection were enrolled into Mommys Milk at the University of California, San Diego. Women donated serial breast milk samples. Breast milk samples were used to probe a multi-coronavirus protein microarray containing full-length proteins and variable length overlapping fragments of SARS-CoV-2 spike (S), envelope (E), membrane (M), nucleocapsid (N), and open reading frame (ORF) proteins. The breast milk samples contained IgA reactive with a variety of SARS-CoV-2 antigens. The most IgA-reactive SARS-CoV-2 proteins were N (42.9% of women responded to 1 [≥] N fragment) and S proteins (23.9% of women responded to [≥] 1 fragment of S1 or S2). Overall, individual COVID-19 cases had diverse and unique milk IgA profiles over the course of follow-up since onset of SARS-CoV-2 symptoms.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Loss of recognition of SARS-CoV-2 B.1.351 variant spike epitopes but overall preservation of T cell immunity 92%
- The effect of anti-SARS-CoV-2 monoclonal antibody, bamlanivimab, on endogenous immune response to COVID-19 vaccination 92%
- COVID-19 mRNA vaccines drive differential Fc-functional profiles in pregnant, lactating, and non-pregnant women 91%
Similar papers in this journal
- Systemic and mucosal antibody secretion specific to SARS-CoV-2 during mild versus severe COVID-19 92%
- Network Analysis Reveals Protein Modules Associated with Childhood Respiratory Diseases 90%
- Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance. 89%
Similar papers in this journal
- Serological profiles of pan-coronavirus-specific responses in COVID-19 patients using a multiplexed electro-chemiluminescence-based testing platform 93%
- SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infection 93%
- Immunogenic Amino Acid Motifs and Linear Epitopes of COVID-19 mRNA Vaccines 93%
Similar papers in this journal
- Novel ELISA protocol links pre-existing SARS-CoV-2 reactive antibodies with endemic coronavirus immunity and age and reveals improved serologic identification of acute COVID-19 via multi-parameter detection 94%
- Harnessing mRNA for the expression of monoclonal IgG and IgA in non-human primates. 93%
- Immune and behavioral correlates of protection against symptomatic post-vaccination SARS-CoV-2 infection 93%
Similar papers in this journal
- Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents 93%
- Autoantigen profiling reveals a shared post-COVID signature in fully recovered and Long COVID patients 93%
- Balance between maternal antiviral response and placental transfer of protection in gestational SARS-CoV-2 infection 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.