Elevated levels of the cytokine LIGHT in Crohn's disease
Cardinale, C. J.; Abrams, D. J.; Mentch, F. D.; Cardinale, J. A.; Kao, C.; Sleiman, P. M.; Hakonarson, H.
Show abstract
LIGHT, encoded by the TNFSF14 gene, is a cytokine belonging to the tumor necrosis factor superfamily. Upon binding to its receptors, HVEM and LTBR, it activates inflammatory responses. We used a single-molecule immunoassay to determine the circulating levels of free LIGHT in plasma from pediatric patients with Crohns disease (N = 183) and a panel of healthy pediatric reference samples (N = 9). LIGHT levels were greatly elevated in Crohns disease (average of 305 pg/ml versus 57 pg/ml in controls, P < 0.0001). We performed correlational analyses between LIGHT levels and the clinical characteristics of the Crohns cohort, including age, Montreal classification, family history, medical/surgical therapy, and routine blood test parameters. We found statistically significant correlation between white blood cell count and free LIGHT (P < 0.046). Our results support the hypothesis that elevated levels of the cytokine contribute to the pathology of Crohns disease and that therapies to neutralize free LIGHT with antibodies may be beneficial.
Matching journals
The top 1 journal accounts for 50% of the predicted probability mass.
Similar papers in this journal
- Antibody Responses to SARS-CoV-2 after Infection or Vaccination in Children and Young Adults with Inflammatory Bowel Disease 95%
- Epithelial cell biomarkers are predictive of response to biologic agents in Crohn's disease 95%
- Molecular network analyses implicate death-associated protein kinase 3 (DAPK3) as a key factor in colitis-associated dysplasia progression 94%
Similar papers in this journal
- High circulating elafin levels are associated with Crohn’s disease-associated intestinal strictures 94%
- Colonic mucosal associated invariant T cells in Crohn’s disease have a diverse and non-public T cell receptor beta chain repertoire 93%
- A Multi-Mineral Intervention To Improve Disease-Related And Mechanistic Biomarkers In Ulcerative Colitis Patients 93%
Similar papers in this journal
Similar papers in this journal
- Relationship Between Patient Sex and Serum Tumor Necrosis Factor Antagonist Drug and Anti-Drug Antibody Concentrations in Inflammatory Bowel Disease; A Nationwide Cohort Study 93%
- Cell-matrix adhesion contributes to permeability control in human colon organoids 91%
- Risk factors for infection, predictors of severe disease and antibody response to COVID-19 in patients with rheumatic diseases in Portugal – a multicentre, nationwide study 89%
Similar papers in this journal
- Infant and Adult Human Intestinal Enteroids are Morphologically and Functionally Distinct 89%
- Protection from lethal Clostridioides difficile infection via intraspecies competition for co-germinant 89%
- Intestinal inflammation reversibly alters the microbiota to drive susceptibility to Clostridioides difficile colonization in a mouse model of colitis 89%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.