Back

Molecular Mechanisms for Frequency Specificity in a Drosophila Hearing Organ

Hu, Y.; Jia, Y.; Deng, T.; Liu, T.; Zhang, W.

2021-07-12 neuroscience
10.1101/2021.07.11.451973 bioRxiv
Show abstract

Discrimination for sound frequency is essential for auditory communications in animals. Here, by combining in vivo calcium imaging and behavioral assay, we found that Drosophila larvae can sense a wide range of sound frequency and the behavioral specificity is mediated with the selectivity of the lch5 chordotonal organ neurons to sounds that forms a combinatorial coding of frequency. We also disclosed that Brivido1 (Brv1) and Piezo-like (Pzl), each expresses in a subset of lch5 neurons and mediate hearing sensation to certain frequency ranges. Intriguingly, mouse Piezo2 can rescue pzl-mutants phenotypes, suggesting a conserved role of the Piezo family proteins in high-frequency hearing.

Matching journals

The top 3 journals account for 50% of the predicted probability mass.

1
National Science Review
◐ 22 papers in training set
Top 0.1%
22.9%
2
Nature Communications
○ 4913 papers in training set
Top 10%
14.6%
3
eLife
● 5422 papers in training set
Top 3%
12.6%
50% of probability mass above
4
Advanced Science
○ 249 papers in training set
Top 3%
4.9%
5
Cell Reports
○ 1338 papers in training set
Top 9%
4.9%
6
Science Advances
● 1098 papers in training set
Top 4%
4.0%
7
Cell Research
○ 49 papers in training set
Top 0.4%
3.6%
8
Science China Life Sciences
○ 26 papers in training set
Top 0.4%
3.1%
9
Genomics, Proteomics & Bioinformatics
◐ 171 papers in training set
Top 2%
2.6%
10
Proceedings of the National Academy of Sciences
● 2130 papers in training set
Top 27%
2.1%
11
Neuroscience Bulletin
○ 11 papers in training set
Top 0.2%
2.1%
12
Cell Discovery
○ 54 papers in training set
Top 3%
1.7%
13
Science Bulletin
○ 22 papers in training set
Top 0.4%
1.5%
14
PLOS Biology
● 408 papers in training set
Top 11%
1.5%
15
Cell
○ 370 papers in training set
Top 13%
1.4%
16
PLOS Genetics
● 756 papers in training set
Top 11%
1.2%
17
Communications Biology
○ 886 papers in training set
Top 18%
0.9%
18
iScience
○ 1063 papers in training set
Top 29%
0.8%
19
Developmental Cell
○ 168 papers in training set
Top 11%
0.8%
20
Science
● 429 papers in training set
Top 19%
0.8%
21
Current Biology
○ 596 papers in training set
Top 14%
0.8%
22
Nucleic Acids Research
◐ 1128 papers in training set
Top 18%
0.7%
23
Neuron
○ 282 papers in training set
Top 9%
0.7%
24
Protein & Cell
◐ 25 papers in training set
Top 3%
0.7%
25
The Journal of Neuroscience
● 928 papers in training set
Top 9%
0.7%
26
Molecular Cell
○ 308 papers in training set
Top 11%
0.5%
27
Genome Biology
○ 555 papers in training set
Top 9%
0.5%
28
Human Molecular Genetics
◐ 130 papers in training set
Top 4%
0.5%
29
Journal of Advanced Research
○ 15 papers in training set
Top 1%
0.5%
30
Cell Chemical Biology
○ 81 papers in training set
Top 5%
0.5%