Novel method for clarifying faster interstitial flow in the intimal side of the aorta under intraluminal pressurization
Fukui, W.; Ujihara, Y.; Nakamura, M.; Sugita, S.
Show abstract
Hypertension causes aortic thickening, especially on the intimal side. Although the production of the extracellular matrix is observed, the type of mechanical stress that produces this response remains unclear. In this study, we hypothesize that the interstitial flow causes the thickening. To validate this claim, we proposed a novel method to measure the velocity distribution in the radial direction in the aorta, which has been unclear. A fluorescent dye was introduced in the lumen of the mouse thoracic aorta ex vivo, intraluminal pressure was applied, and a time-lapse image in the radial-circumferential plane was acquired under a two-photon microscope. The flow of the fluorescent dye from the intimal to the adventitial sides in the aorta was successfully observed. The acquired image was converted to a radial-time image (i.e., kymograph), and the flow velocity was quantified by applying the one-dimensional advection-diffusion equation to the fluorescent images. The results revealed a higher interstitial flow velocity in the aortic walls under higher intraluminal pressure and a higher velocity on the more intimal side. Thus, the interstitial flow is a candidate for the mechanical stress causing hyperplasia of the aorta under hypertension.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Analysis of vascular architecture and parenchymal damage generated by reduced blood perfusion in decellularized porcine kidneys using a gray level co-occurrence matrix 92%
- Cardiovascular Hemodynamics in Mice with Tumor Necrosis Factor Receptor - Associated Factor 2 Mediated Cytoprotection in the Heart 91%
- Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress. 91%
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Experiments and Simulations to Assess Exercise-Induced Pressure Drop Across Aortic Coarctations 93%
- Stretching the Limits: From Planar-Biaxial Stress-Stretch to Arterial Pressure-Diameter 90%
- Remodeling-mediated changes in left ventricular mechanics under settings of chronic pressure overload and exercise 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.