A novel α/β T-cell subpopulation defined by recognition of EPCR
Arrondo, E. E.; Moran-Garrido, M.; Saiz, J.; Barbas, C.; Dichiara Rodriguez, M. G.; Ramirez, N.; Lopez-Sagaseta, J.
Show abstract
T-cell self-recognition of antigen presenting molecules is led by antigen-dependent or independent mechanisms. The endothelial protein C receptor (EPCR) shares remarkable similarity with CD1d, including a lipid binding cavity. We have identified EPCR-specific /{beta} T-cells in the peripheral blood of healthy donors. The average frequency in the CD3+ leukocyte pool is comparable to other autoreactive T-cell subsets that specifically bind MHC-like receptors. Alteration of the EPCR lipid cargo, revealed by X-ray diffraction studies, points to a prevalent, yet not exclusive, lipid-independent self-recognition. In addition, we solve the EPCR lipidome, and detect species not yet described as EPCR ligands. These studies report, for the first time, novel recognition by circulating /{beta} T-cells and provide grounds for EPCR and lipid mediated T-cell restriction.
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