On the topochronic map of the human brain dynamics
Sorrentino, P.; Petkoski, S.; Sparaco, M.; Troisi Lopez, E.; Rucco, R.; Signoriello, E.; Baselice, F.; Bonavita, S.; Pirozzi, M. A.; Quarantelli, M.; Sorrentino, G.; Jirsa, V.
Show abstract
Two structurally connected brain regions are more likely to interact, with the lengths of the structural bundles, their widths, myelination, and the topology of the structural connectome influencing the timing of the interactions. We introduce an in vivo approach for measuring functional delays across the whole brain using magneto/electroencephalography and integrating them with the structural bundles. The resulting topochronic map of the functional delays/velocities shows that larger bundles have faster velocities. We estimated the topochronic map in multiple sclerosis patients, who have damaged myelin sheaths, and controls, demonstrating greater delays in patients across the network and that structurally lesioned tracks were slowed down more than unaffected ones. We provide a novel framework for estimating functional transmission delays in vivo at the single-subject and single-fiber level. One-Sentence SummaryA non-invasive estimation of the individual deterministic spatio-temporal scaffold underlying the evolution of brain dynamics.
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