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Test negative designs with uncertainty, sensitivity, and specificity
2021-06-27
epidemiology
Title + abstract only
View on medRxiv
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Test-negative designs (TNDs) can be used to estimate vaccine effectiveness by comparing the relative rates of the target disease and symptomatically similar diseases among vaccinated and unvaccinated populations. However, the diagnostic tests used to identify the target disease typically suffer from imperfect sensitivity and specificity, leading to biased vaccine effectiveness estimates. Here we present a solution to this problem via a Bayesian statistical model which can either incorporate poin...
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