LSD induces increased signalling entropy in rats' prefrontal cortex
Savino, A.; Nichols, C. D.
Show abstract
Psychedelic drugs are gaining attention from the scientific community as potential new compounds for the treatment of psychiatric diseases such as mood and substance use disorders. The 5-HT2A receptor has been identified as the main molecular target, and early studies pointed to an effect on the expression of neuroplasticity genes. Analysing RNA-seq data from the prefrontal cortex of rats chronically treated with lysergic acid diethylamide (LSD), we describe the psychedelic-induced rewiring of gene co-expression networks, which become less centralized but more complex, with an overall increase in signalling entropy, typical of highly plastic systems. Intriguingly, signalling entropy mirrors, at the molecular level, the increased brain entropy reported through neuroimaging studies in human, suggesting the underlying mechanisms of higher-order phenomena. Moreover, from the analysis of network topology we identify potential transcriptional regulators and imply different cell types in psychedelics activity.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Pre-Implantation Alcohol Exposure Induces Lasting Sex-Specific DNA Methylation Programming Errors in the Developing Forebrain 91%
- Gender Affirming Hormone Therapy induces specific DNA methylation changes in blood 90%
- Effect of short-term prescription opioids on DNA methylation of the OPRM1 promoter 90%
Similar papers in this journal
Similar papers in this journal
- Cortical lipids containing choline mediate cannabinoid-induced cognitive improvement 90%
- Cross-pathway integration of cAMP signals through cGMP and calcium-regulated phosphodiesterases in mouse striatal cholinergic interneurons. 90%
- A Systematic Assessment of Robustness in CNS Safety Pharmacology 88%
Similar papers in this journal
- Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia 94%
- Dysfunctional Hippocampal-Prefrontal Network Underlies a Multidimensional Neuropsychiatric Phenotype following Early-Life Seizure 94%
- Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats 93%
Similar papers in this journal
- Downregulated NPAS4 in multiple brain regions is associated with Major Depressive Disorder 92%
- Deletion of the Clock Gene Period2 (Per2) in Glial Cells Alters Mood-Related Behavior in Mice 92%
- A mesocorticolimbic dopamine gene network moderates the effect of early adversity on the risk for psychiatric and cardio-metabolic comorbidities 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.