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Reconstruction of genome-scale metabolic model for Hansenula polymorpha using RAVEN toolbox

Zorrilla, F.; Kerkhoven, E. J.

2021-06-18 systems biology
10.1101/2021.06.18.448943 bioRxiv
Show abstract

Genome scale metabolic models (GEMs) provide a useful framework for modeling the metabolism of microorganisms. While the applications of GEMs are wide and far reaching, the reconstruction and continuous curation of such models can be perceived as a tedious and time consuming task. Using the RAVEN toolbox, this protocol practically demonstrates how researchers can create their own GEMs using a homology based approach. To provide a complete example, we reconstruct a draft GEM for the industrially relevant yeast Hansenula polymorpha.

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